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  "Package": "rpact",
  "Title": "Confirmatory Adaptive Clinical Trial Design and Analysis",
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  "Date": "2026-03-04",
  "Authors@R": "c(\nperson(\ngiven = \"Gernot\",\nfamily = \"Wassmer\",\nemail = \"gernot.wassmer@rpact.com\",\ncomment = c(ORCID = \"0000-0001-9397-1794\"),\nrole = c(\"aut\")\n),\nperson(\ngiven = \"Friedrich\",\nfamily = \"Pahlke\",\nemail = \"friedrich.pahlke@rpact.com\",\ncomment = c(ORCID = \"0000-0003-2105-2582\"),\nrole = c(\"aut\", \"cre\")\n),\nperson(\ngiven = \"Till\",\nfamily = \"Jensen\",\nemail = \"till.jensen@rpact.com\",\nrole = c(\"ctb\")\n),\nperson(\ngiven = \"Daniel\",\nfamily = \"Sabanes Bove\",\nemail = \"daniel.sabanes_bove@rconis.com\",\ncomment = c(ORCID = \"0000-0002-0176-9239\"),\nrole = c(\"ctb\")\n),\nperson(\ngiven = \"Stephen\",\nfamily = \"Schueuerhuis\",\nemail = \"stephen.schueuerhuis@charite.de\",\ncomment = c(ORCID = \"0009-0006-3124-6056\"),\nrole = c(\"ctb\")\n),\nperson(\ngiven = \"Tobias\",\nfamily = \"Muetze\",\nemail = \"tobias.muetze@novartis.com\",\ncomment = c(ORCID = \"0000-0002-4111-1941\"),\nrole = c(\"ctb\")\n),\nperson(\n\"RPACT GmbH\",\nrole = c(\"cph\", \"fnd\"),\nemail = \"info@rpact.com\"\n))",
  "Description": "Design and analysis of confirmatory adaptive clinical\ntrials with continuous, binary, and survival endpoints\naccording to the methods described in the monograph by Wassmer\nand Brannath (2025) <doi:10.1007/978-3-031-89669-9>. This\nincludes classical group sequential as well as multi-stage\nadaptive hypotheses tests that are based on the combination\ntesting principle.",
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  "Repository": "https://rpact-com.r-universe.dev",
  "Date/Publication": "2026-05-28 07:49:23 UTC",
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        "data.frame"
      ],
      "fields": [
        "stages",
        "subsets",
        "sampleSizes1",
        "sampleSizes2",
        "events1",
        "events2",
        "overallSampleSizes1",
        "overallSampleSizes2",
        "overallEvents1",
        "overallEvents2"
      ],
      "rows": 12,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataEnrichmentSurvival",
      "title": "Enrichment Dataset of Survival Data",
      "object": "dataEnrichmentSurvival",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "subsets",
        "overallEvents",
        "overallAllocationRatios",
        "overallLogRanks",
        "events",
        "allocationRatios",
        "logRanks"
      ],
      "rows": 9,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataEnrichmentSurvivalStratified",
      "title": "Stratified Enrichment Dataset of Survival Data",
      "object": "dataEnrichmentSurvivalStratified",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "subsets",
        "overallEvents",
        "overallAllocationRatios",
        "events",
        "allocationRatios",
        "expectedEvents",
        "varianceEvents",
        "overallExpectedEvents",
        "overallVarianceEvents"
      ],
      "rows": 12,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataMeans",
      "title": "One-Arm Dataset of Means",
      "object": "dataMeans",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "sampleSizes",
        "means",
        "stDevs",
        "overallSampleSizes",
        "overallMeans",
        "overallStDevs"
      ],
      "rows": 3,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataMultiArmMeans",
      "title": "Multi-Arm Dataset of Means",
      "object": "dataMultiArmMeans",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "sampleSizes1",
        "sampleSizes2",
        "sampleSizes3",
        "sampleSizes4",
        "means1",
        "means2",
        "means3",
        "means4",
        "stDevs1",
        "stDevs2",
        "stDevs3",
        "stDevs4",
        "overallSampleSizes1",
        "overallSampleSizes2",
        "overallSampleSizes3",
        "overallSampleSizes4",
        "overallMeans1",
        "overallMeans2",
        "overallMeans3",
        "overallMeans4",
        "overallStDevs1",
        "overallStDevs2",
        "overallStDevs3",
        "overallStDevs4"
      ],
      "rows": 2,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataMultiArmRates",
      "title": "Multi-Arm Dataset of Rates",
      "object": "dataMultiArmRates",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "sampleSizes1",
        "sampleSizes2",
        "sampleSizes3",
        "events1",
        "events2",
        "events3",
        "overallSampleSizes1",
        "overallSampleSizes2",
        "overallSampleSizes3",
        "overallEvents1",
        "overallEvents2",
        "overallEvents3"
      ],
      "rows": 2,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataMultiArmSurvival",
      "title": "Multi-Arm Dataset of Survival Data",
      "object": "dataMultiArmSurvival",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "overallEvents1",
        "overallEvents2",
        "overallAllocationRatios1",
        "overallAllocationRatios2",
        "overallLogRanks1",
        "overallLogRanks2",
        "events1",
        "events2",
        "allocationRatios1",
        "allocationRatios2",
        "logRanks1",
        "logRanks2"
      ],
      "rows": 2,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataRates",
      "title": "One-Arm Dataset of Rates",
      "object": "dataRates",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "sampleSizes",
        "events",
        "overallSampleSizes",
        "overallEvents"
      ],
      "rows": 4,
      "table": true,
      "tojson": true
    },
    {
      "name": "dataSurvival",
      "title": "One-Arm Dataset of Survival Data",
      "object": "dataSurvival",
      "class": [
        "data.frame"
      ],
      "fields": [
        "stages",
        "overallEvents",
        "overallAllocationRatios",
        "overallLogRanks",
        "events",
        "allocationRatios",
        "logRanks"
      ],
      "rows": 3,
      "table": true,
      "tojson": true
    },
    {
      "name": "rawDataTwoArmNormal",
      "title": "Raw Dataset Of A Two Arm Continuous Outcome With Covariates",
      "object": "rawDataTwoArmNormal",
      "class": [
        "data.frame"
      ],
      "fields": [
        "subject",
        "stage",
        "group",
        "visit",
        "outcome",
        "gender",
        "covariate",
        "seed"
      ],
      "rows": 522,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "as251Normal",
      "title": "Algorithm AS 251: Normal Distribution",
      "topics": [
        "as251Normal"
      ]
    },
    {
      "page": "as251StudentT",
      "title": "Algorithm AS 251: Student T Distribution",
      "topics": [
        "as251StudentT"
      ]
    },
    {
      "page": "getAccrualTime",
      "title": "Get Accrual Time",
      "topics": [
        "getAccrualTime"
      ]
    },
    {
      "page": "getAnalysisResults",
      "title": "Get Analysis Results",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getAnalysisResults"
      ]
    },
    {
      "page": "getClosedCombinationTestResults",
      "title": "Get Closed Combination Test Results",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getClosedCombinationTestResults"
      ]
    },
    {
      "page": "getClosedConditionalDunnettTestResults",
      "title": "Get Closed Conditional Dunnett Test Results",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getClosedConditionalDunnettTestResults"
      ]
    },
    {
      "page": "getConditionalPower",
      "title": "Get Conditional Power",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getConditionalPower"
      ]
    },
    {
      "page": "getConditionalRejectionProbabilities",
      "title": "Get Conditional Rejection Probabilities",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getConditionalRejectionProbabilities"
      ]
    },
    {
      "page": "getData",
      "title": "Get Simulation Data",
      "topics": [
        "getData",
        "getData.SimulationResults"
      ]
    },
    {
      "page": "getDataset",
      "title": "Get Dataset",
      "topics": [
        "getDataSet",
        "getDataset"
      ]
    },
    {
      "page": "getDesignCharacteristics",
      "title": "Get Design Characteristics",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getDesignCharacteristics"
      ]
    },
    {
      "page": "getDesignConditionalDunnett",
      "title": "Get Design Conditional Dunnett Test",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getDesignConditionalDunnett"
      ]
    },
    {
      "page": "getDesignFisher",
      "title": "Get Design Fisher",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getDesignFisher"
      ]
    },
    {
      "page": "getDesignGroupSequential",
      "title": "Get Design Group Sequential",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getDesignGroupSequential"
      ]
    },
    {
      "page": "getDesignInverseNormal",
      "title": "Get Design Inverse Normal",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getDesignInverseNormal"
      ]
    },
    {
      "page": "getDesignSet",
      "title": "Get Design Set",
      "topics": [
        "getDesignSet"
      ]
    },
    {
      "page": "getEventProbabilities",
      "title": "Get Event Probabilities",
      "topics": [
        "getEventProbabilities"
      ]
    },
    {
      "page": "getFinalConfidenceInterval",
      "title": "Get Final Confidence Interval",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getFinalConfidenceInterval"
      ]
    },
    {
      "page": "getFinalPValue",
      "title": "Get Final P Value",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getFinalPValue"
      ]
    },
    {
      "page": "getFutilityBounds",
      "title": "Get Futility Bounds",
      "topics": [
        "getFutilityBounds"
      ]
    },
    {
      "page": "getGroupSequentialProbabilities",
      "title": "Get Group Sequential Probabilities",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getGroupSequentialProbabilities"
      ]
    },
    {
      "page": "getNumberOfSubjects",
      "title": "Get Number Of Subjects",
      "topics": [
        "getNumberOfSubjects"
      ]
    },
    {
      "page": "getObservedInformationRates",
      "title": "Get Observed Information Rates",
      "topics": [
        "getObservedInformationRates"
      ]
    },
    {
      "page": "getOutputFormat",
      "title": "Get Output Format",
      "concept": [
        "output formats"
      ],
      "topics": [
        "getOutputFormat"
      ]
    },
    {
      "page": "getPerformanceScore",
      "title": "Get Performance Score",
      "topics": [
        "getPerformanceScore"
      ]
    },
    {
      "page": "getPiecewiseSurvivalTime",
      "title": "Get Piecewise Survival Time",
      "topics": [
        "getPiecewiseSurvivalTime"
      ]
    },
    {
      "page": "getPowerAndAverageSampleNumber",
      "title": "Get Power And Average Sample Number",
      "concept": [
        "design functions"
      ],
      "topics": [
        "getPowerAndAverageSampleNumber"
      ]
    },
    {
      "page": "getPowerCounts",
      "title": "Get Power Counts",
      "concept": [
        "power functions"
      ],
      "topics": [
        "getPowerCounts"
      ]
    },
    {
      "page": "getPowerMeans",
      "title": "Get Power Means",
      "concept": [
        "power functions"
      ],
      "topics": [
        "getPowerMeans"
      ]
    },
    {
      "page": "getPowerRates",
      "title": "Get Power Rates",
      "concept": [
        "power functions"
      ],
      "topics": [
        "getPowerRates"
      ]
    },
    {
      "page": "getPowerSurvival",
      "title": "Get Power Survival",
      "concept": [
        "power functions"
      ],
      "topics": [
        "getPowerSurvival"
      ]
    },
    {
      "page": "getRawData",
      "title": "Get Simulation Raw Data for Survival",
      "topics": [
        "getRawData"
      ]
    },
    {
      "page": "getRepeatedConfidenceIntervals",
      "title": "Get Repeated Confidence Intervals",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getRepeatedConfidenceIntervals"
      ]
    },
    {
      "page": "getRepeatedPValues",
      "title": "Get Repeated P Values",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getRepeatedPValues"
      ]
    },
    {
      "page": "getSampleSizeCounts",
      "title": "Get Sample Size Counts",
      "concept": [
        "sample size functions"
      ],
      "topics": [
        "getSampleSizeCounts"
      ]
    },
    {
      "page": "getSampleSizeMeans",
      "title": "Get Sample Size Means",
      "concept": [
        "sample size functions"
      ],
      "topics": [
        "getSampleSizeMeans"
      ]
    },
    {
      "page": "getSampleSizeRates",
      "title": "Get Sample Size Rates",
      "concept": [
        "sample size functions"
      ],
      "topics": [
        "getSampleSizeRates"
      ]
    },
    {
      "page": "getSampleSizeSurvival",
      "title": "Get Sample Size Survival",
      "concept": [
        "sample size functions"
      ],
      "topics": [
        "getSampleSizeSurvival"
      ]
    },
    {
      "page": "getSimulationCounts",
      "title": "Get Simulation Counts",
      "topics": [
        "getSimulationCounts"
      ]
    },
    {
      "page": "getSimulationEnrichmentMeans",
      "title": "Get Simulation Enrichment Means",
      "topics": [
        "getSimulationEnrichmentMeans"
      ]
    },
    {
      "page": "getSimulationEnrichmentRates",
      "title": "Get Simulation Enrichment Rates",
      "topics": [
        "getSimulationEnrichmentRates"
      ]
    },
    {
      "page": "getSimulationEnrichmentSurvival",
      "title": "Get Simulation Enrichment Survival",
      "topics": [
        "getSimulationEnrichmentSurvival"
      ]
    },
    {
      "page": "getSimulationMeans",
      "title": "Get Simulation Means",
      "topics": [
        "getSimulationMeans"
      ]
    },
    {
      "page": "getSimulationMultiArmMeans",
      "title": "Get Simulation Multi-Arm Means",
      "topics": [
        "getSimulationMultiArmMeans"
      ]
    },
    {
      "page": "getSimulationMultiArmRates",
      "title": "Get Simulation Multi-Arm Rates",
      "topics": [
        "getSimulationMultiArmRates"
      ]
    },
    {
      "page": "getSimulationMultiArmSurvival",
      "title": "Get Simulation Multi-Arm Survival",
      "topics": [
        "getSimulationMultiArmSurvival"
      ]
    },
    {
      "page": "getSimulationRates",
      "title": "Get Simulation Rates",
      "topics": [
        "getSimulationRates"
      ]
    },
    {
      "page": "getSimulationSurvival",
      "title": "Get Simulation Survival",
      "topics": [
        "getSimulationSurvival"
      ]
    },
    {
      "page": "getStageResults",
      "title": "Get Stage Results",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getStageResults"
      ]
    },
    {
      "page": "getTestActions",
      "title": "Get Test Actions",
      "concept": [
        "analysis functions"
      ],
      "topics": [
        "getTestActions"
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    },
    {
      "page": "knit_print.SummaryFactory",
      "title": "Print Summary Factory in Markdown Code Chunks",
      "topics": [
        "knit_print.SummaryFactory"
      ]
    },
    {
      "page": "mvnprd",
      "title": "Original Algorithm AS 251: Normal Distribution",
      "topics": [
        "mvnprd"
      ]
    },
    {
      "page": "mvstud",
      "title": "Original Algorithm AS 251: Student T Distribution",
      "topics": [
        "mvstud"
      ]
    },
    {
      "page": "fetch.ParameterSet",
      "title": "Extract a single parameter",
      "topics": [
        "fetch",
        "fetch.ParameterSet",
        "obtain",
        "obtain.ParameterSet"
      ]
    },
    {
      "page": "plot.AnalysisResults",
      "title": "Analysis Results Plotting",
      "topics": [
        "plot.AnalysisResults"
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    {
      "page": "plot.Dataset",
      "title": "Dataset Plotting",
      "topics": [
        "plot.Dataset"
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    {
      "page": "plot.EventProbabilities",
      "title": "Event Probabilities Plotting",
      "topics": [
        "plot.EventProbabilities"
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    {
      "page": "plot.NumberOfSubjects",
      "title": "Number Of Subjects Plotting",
      "topics": [
        "plot.NumberOfSubjects"
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    {
      "page": "plot.ParameterSet",
      "title": "Parameter Set Plotting",
      "topics": [
        "plot.ParameterSet"
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    {
      "page": "plot.SimulationResults",
      "title": "Simulation Results Plotting",
      "topics": [
        "plot.SimulationResults"
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      "page": "plot.StageResults",
      "title": "Stage Results Plotting",
      "topics": [
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    {
      "page": "plot.SummaryFactory",
      "title": "Summary Factory Plotting",
      "topics": [
        "plot.SummaryFactory"
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    {
      "page": "plot.TrialDesign",
      "title": "Trial Design Plotting",
      "topics": [
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        "plot.TrialDesignCharacteristics"
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    },
    {
      "page": "plot.TrialDesignPlan",
      "title": "Trial Design Plan Plotting",
      "topics": [
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    },
    {
      "page": "plot.TrialDesignSet",
      "title": "Trial Design Set Plotting",
      "topics": [
        "plot.TrialDesignSet"
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    {
      "page": "plot.TrialDesignSummaries",
      "title": "Plot Trial Design Summaries",
      "topics": [
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      "page": "getAvailablePlotTypes",
      "title": "Get Available Plot Types",
      "topics": [
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        "plotTypes"
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    },
    {
      "page": "print.SummaryFactory",
      "title": "Summary Factory Printing",
      "topics": [
        "print.SummaryFactory"
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    },
    {
      "page": "print.TrialDesignCharacteristics",
      "title": "Trial Design Characteristics Printing",
      "topics": [
        "print.TrialDesignCharacteristics"
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    },
    {
      "page": "print.TrialDesignSummaries",
      "title": "Print Trial Design Summaries",
      "topics": [
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    },
    {
      "page": "getObjectRCode",
      "title": "Get Object R Code",
      "topics": [
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        "rcmd"
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    },
    {
      "page": "readDataset",
      "title": "Read Dataset",
      "topics": [
        "readDataset"
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    {
      "page": "readDatasets",
      "title": "Read Multiple Datasets",
      "topics": [
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    {
      "page": "rpact",
      "title": "rpact - Confirmatory Adaptive Clinical Trial Design and Analysis",
      "topics": [
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        "rpact"
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      "concept": [
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      "page": "testPackage",
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      "topics": [
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      "page": "utilitiesForPiecewiseExponentialDistribution",
      "title": "The Piecewise Exponential Distribution",
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      "page": "writeDataset",
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      "topics": [
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      "page": "writeDatasets",
      "title": "Write Multiple Datasets",
      "topics": [
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  "_readme": "https://github.com/rpact-com/rpact/raw/HEAD/README.md",
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      "filename": "rpact_getting_started.html",
      "title": "Getting started with rpact",
      "author": "Friedrich Pahlke and Gernot Wassmer",
      "engine": "knitr::rmarkdown",
      "headings": [
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      "created": "2022-07-15 11:17:17",
      "modified": "2025-12-15 14:32:40",
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